2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one → HCID 178518707, compound

HRID 523487Notes

Reaction equation

HRID 523487 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[N:14]1([C:20]2[N:25]=[C:24]([OH:26])[CH:23]=[CH:22][CH:21]=2)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)CC(C)C>[OH:26][C:24]1[N:25]=[C:20]([N:14]2[CH2:19][CH2:18][N:17]([C:3]3[NH:12][C:11](=[O:13])[C:10]4[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=4[N:4]=3)[CH2:16][CH2:15]2)[CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-oneHCID 178516080HCID 178516080, compound

Product 1

HCID 178518707HCID 178518707, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and 6-piperazin-1-ylpyridin-2-ol (91.3 mg; 0.51 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 9 and worked up. The crude product obtained after conventional work-up is purified by column chromatography, triturated with diethyl ether, filtered off with suction and dried; yield: 17 mg (10%), crystals;

Sources & evidence

ORD record
ord-c567514cf5194aaa8e86f18bc9143578
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

Loading…