Morpholin-4-yl-piperazin-1-yl-methanone → HCID 136268346, compound

HRID 523491Notes

Reaction equation

HRID 523491 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[N:14]1([C:20]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)CC(C)C.C(#N)C>[N:22]1([C:20]([N:14]2[CH2:15][CH2:16][N:17]([C:3]3[NH:12][C:11](=[O:13])[C:10]4[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=4[N:4]=3)[CH2:18][CH2:19]2)=[O:21])[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1

Participants

5

Reactant 2

HCID 700139Morpholin-4-yl-piperazin-1-yl-methanoneHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 136268346HCID 136268346, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and piperazinocarboxylic acid morpholide (152.3 mg; 0.76 mmol) are reacted in isoamyl alcohol (1.5 ml) in accordance with the procedure for Example 1 (reaction time 8 h) and worked up. The crystals obtained are dissolved in acetonitrile and water and freeze-dried; yield: 38 mg (21%), crystals;

Workup

  1. customThe crystals obtained
  2. dry with materialwater and freeze-dried

Sources & evidence

ORD record
ord-3d1e96a97de24f42a7e1f5b9491026b9
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

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