Triethylamine → HCID 136268349, compound

HRID 523492Notes

Reaction equation

HRID 523492 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][C:21](=[O:29])[CH2:22][N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:15]=1.C(N(CC)CC)C>C(O)CC(C)C>[O:13]=[C:11]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=[C:3]([N:26]2[CH2:27][CH2:28][N:23]([CH2:22][C:21]([NH:20][C:16]3[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=3)=[O:29])[CH2:24][CH2:25]2)[NH:12]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2737191N-3-Pyridinyl-1-piperazineacetamideHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 136268349HCID 136268349, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol), N-(3-pyridyl)-2-(piperazin-1-yl)acetamide * 3HCl (251.9 mg; 0.76 mmol) and triethylamine (282.5 μl; 2.04 mmol) are reacted in isoamyl alcohol (2 ml) in accordance with the procedure for Example 1 (reaction time 4 h) and worked up.

Sources & evidence

ORD record
ord-91aa8f5e047f48509a9749cd2dee014e
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

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