Ethanol → HCID 68479385, compound

HRID 523521Notes

Reaction equation

HRID 523521 reaction equation
C[O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([CH3:15])[C:10](=[O:14])[NH:11]2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].C(O)C.O>O1CCCC1>[CH2:16]([C:9]1([CH3:15])[C:8]2[C:12](=[CH:13][C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=2)[NH:11][C:10]1=[O:14])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 68483995HCID 68483995, compound

Product 1

HCID 68479385HCID 68479385, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 1C, by reacting 3-Benzyl-3-methyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester (1.06 mmol) obtained in Example 19(B), sodium hydroxide (260 mg, 6.5 mmol), ethanol (10 ml) and water (1 ml) in tetrahydrofuran (10 ml), expected derivative was obtained as a white solid.

Workup

  1. customexpected derivative was obtained as a white solid

Sources & evidence

ORD record
ord-0f8d681e8e8a4d1a986d96b3a598efb1
Source dataset
uspto-grants-2016_05
Patent number
US09339486B2

Reaction notes

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