反应详情

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 150 mg, 0.738 mmol) was reacted with 2-bromo-4-(trifluoromethyl)pyridine (200.3 mg, 0.88 mmol), 1,4-dioxane (5 mL), copper iodide (14.03 mg, 0.073 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (10.49 mg, 0.073 mmol) and potassium phosphate (469.9 mg, 2.21 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 182.5 mg of the product (71% yield).

1. customreagents and reaction conditions
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (1% methanol in CHCl3)