反应详情

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 5-bromo-2,3-dihydro-1H-indene (132 mg, 0.5418 mmol), 1,4-dioxane (4 mL), copper iodide (9.5 mg, 0.0492 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (7.0 mg, 0.0492 mmol) and potassium phosphate (261 mg, 1.231 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in CHCl3) afforded 12 mg of the product (8% yield).

1. customreagents and reaction conditions
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (1.5% methanol in CHCl3)