反应详情

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropyl-pyridin-3-yl)-imidazolidin-2-one (I-1d: 100 mg, 0.4926 mmol) was reacted with 5-bromo-2-fluoro-3-methyl-benzo[b]thiophene (I-24c: 120 mg, 0.4926 mmol), copper iodide (9.3 mg, 0.04926 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (7.0 mg, 0.04926 mmol), potassium phosphate (313 mg, 1.4778 mmol) and 1,4-dioxane (5 ml) to afford the crude product. Purification by column chromatography on silica gel (2% methanol in chloroform) afforded 120 mg of product (66% yield).

1. customreagents and reaction conditions
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (2% methanol in chloroform)