反应详情

Platinum oxide (20 mg) was added to a mixture of 3-bromo-4-cyclopent-1-enyl-pyridine (I-34b: 140 mg, 0.622 mmol) in toluene (5 mL) and stirred overnight under hydrogen atmosphere. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered through celite pad and washed with toluene and concentrated to afford crude product. Purification by column chromatography (8% ethyl acetate in hexane) afforded 98 mg of the product (71% yield).

1. filtrationThe reaction mixture was filtered through celite pad
2. washwashed with toluene
3. concentrationconcentrated
4. customto afford crude product
5. customPurification by column chromatography (8% ethyl acetate in hexane)