反应详情

温度

150 °C

POCl3 (5 mL) was added to 2-cyclopropylpyrimidin-4-ol (100 mg, 0.735 mmol) and refluxed at 150° C. for 2.5 hours. The resulting mixture was concentrated, the concentrate was basified with dilute sodium bicarbonate solution and diluted with DCM. The organic layer was washed with brine, dried over sodium sulphate and concentrated to afford 125 mg of the crude product as a pale brown liquid.

1. concentrationThe resulting mixture was concentrated
2. additiondiluted with DCM
3. washThe organic layer was washed with brine
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated