反应详情

1-Bromo-4-hydroxy-7-phenylsulfanyl-isoquinoline-3-carboxylic acid (10.0 g), potassium carbonate (3.7 g) and methyl sulfate (3.4 g) were suspended in 500 ml acetone and stirred at reflux overnight. Reaction mixture was concentrated and residue partitioned between 1N hydrochloric acid and ethyl acetate. Organic layer was dried over magnesium sulfate and filtered. Filtrate concentrated to give title compound (9.6 g). MS-(+)-ion M+1=389.9, 391.9.

1. temperatureat reflux overnight
2. customReaction mixture
3. concentrationwas concentrated
4. customresidue partitioned between 1N hydrochloric acid and ethyl acetate
5. dry with materialOrganic layer was dried over magnesium sulfate
6. filtrationfiltered
7. concentrationFiltrate concentrated