Trifluoroacetic acid → HCID 66712988, compound

HRID 523802Notes

Reaction equation

HRID 523802 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][NH:8][C:9]([C:11]1[N:12]=[C:13]([CH3:31])[C:14]2[C:19]([C:20]=1[O:21][CH2:22][CH3:23])=[CH:18][CH:17]=[C:16]([O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH:15]=2)=[O:10])(C)(C)C.FC(F)(F)C(O)=O>>[CH2:22]([O:21][C:20]1[C:19]2[C:14](=[CH:15][C:16]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:17][CH:18]=2)[C:13]([CH3:31])=[N:12][C:11]=1[C:9]([NH:8][CH2:7][C:6]([OH:32])=[O:5])=[O:10])[CH3:23]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66713533HCID 66713533, compound

Product 1

HCID 66712988HCID 66712988, compoundYield 98.6%

Procedure

A mixture of [(4-ethoxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid tert-butyl ester (14 mg, 0.032 mmol) and trifluoroacetic acid (2 ml) was stirred at ambient temperature for 3 h. Then the mixture was concentrated in vacuo and the residue dissolved in EtOH (5 ml). The mixture was evaporated in vacuo to give the title compound as a yellowish solid (12 mg); MS-(−)-ion: M−1=381.1.

Workup

  1. concentrationThen the mixture was concentrated in vacuo
  2. dissolutionthe residue dissolved in EtOH (5 ml)
  3. customThe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-3dc6ad935a20462885fea629117e506f
Source dataset
uspto-grants-2016_05
Patent number
US09339527B2

Reaction notes

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