4-Benzyloxy-1-p-tolyl-isoquinoline-3-carboxylic acid butyl ester → 4-Hydroxy-1-p-tolyl-isoquinoline-3-carboxylic acid butyl ester

HRID 523805Notes

Reaction equation

HRID 523805 reaction equation
[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)[C:11]2[C:16]([C:17]=1[O:18]CC1C=CC=CC=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4]>CCOC(C)=O>[CH2:1]([O:5][C:6]([C:8]1[N:9]=[C:10]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 667127544-Benzyloxy-1-p-tolyl-isoquinoline-3-carboxylic acid butyl ester

Product 1

HCID 667126674-Hydroxy-1-p-tolyl-isoquinoline-3-carboxylic acid butyl ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Synthesized from (4-benzyloxy-1-p-tolyl-isoquinoline-3-carboxylic acid butyl ester in analogy to Example D-78 d) (EtOAc was used as the solvent); MS-(+)-ion: M+1=336.2.

Sources & evidence

ORD record
ord-c579d7dea6104d0caf319f57b97e672c
Source dataset
uspto-grants-2016_05
Patent number
US09339527B2

Reaction notes

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