2-Methoxy-3-(phenylmethoxy)benzeneacetonitrile → HCID 117396777, compound

HRID 523992Notes

Reaction equation

HRID 523992 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([O:18][CH3:19])=[C:11]([CH2:15][C:16]#[N:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N.[Ni]>[CH2:1]([O:8][C:9]1[C:10]([O:18][CH3:19])=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 1173860082-Methoxy-3-(phenylmethoxy)benzeneacetonitrile

Product 1

HCID 117396777HCID 117396777, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

7.7 g (34 mmol) (3-Benzyloxy-2-methoxy-phenyl)-acetonitrile (example XI) in 100 mL methanolic ammonia (c=7 mol/L) are hydrogenated (3 bar, r.t.) using 250 mg Raney-nickel. The reaction mixture is filtered and the solvent is removed in vacuo.

Workup

  1. custom(3 bar, r.t.)
  2. filtrationThe reaction mixture is filtered
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-025905235d474bd89d3d60bb448f96dd
Source dataset
uspto-grants-2016_05
Patent number
US09340510B2

Reaction notes

Loading…