Sulfuryl chloride → HCID 68781764, compound

HRID 523994Notes

Reaction equation

HRID 523994 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.S(Cl)([Cl:16])(=O)=O>CC(O)=O>[Cl:16][C:4]1[C:3]([O:2][CH3:1])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][NH:8][CH2:9]2

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 393566-Methoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 68781764HCID 68781764, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.0 g (31 mmol) 6-Methoxy-1,2,3,4-tetrahydro-isoquinoline in 30 mL AcOH are cooled to 0° C. and 2.7 mL (34 mmol) sulfuryl chloride are added slowly. The resulting mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is treated with toluene/ACN 1:1. The precipitate is filtered off and dried at 40° C. in vacuo.

Workup

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with toluene/ACN 1:1
  3. filtrationThe precipitate is filtered off
  4. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-8dfae1d5ea7a400ca1f00c1e719773b6
Source dataset
uspto-grants-2016_05
Patent number
US09340510B2

Reaction notes

Loading…