反应详情

温度

0 °C

To 0.92 mL (2.2 mmol) lithium aluminum hydride solution (2.4 M in THF) are added dropwise 300 mg (1.01 mmol) 2-bromo-1-cyclopropylmethoxy-3-(2-nitro-vinyl)-benzene (example XX) in 5 mL THF at 0° C. After stirring at 0° C. for 2 h the reaction mixture is quenched by the addition of 36 μL (2.0 mmol) water, 0.50 mL (2.0 mmol) aq. NaOH solution (c=4 mol/L) and 0.11 mL (6.0 mmol) water. The resulting mixture is stirred for 20 min, filtered over celite/Na2SO4 and the filtrate is concentrated by evaporation. The residue is purified by HPLC (ACN/H2O/NH4OH).

1. stirringThe resulting mixture is stirred for 20 min
2. filtrationfiltered over celite/Na2SO4
3. concentrationthe filtrate is concentrated by evaporation
4. customThe residue is purified by HPLC (ACN/H2O/NH4OH)