Potassium Carbonate → 2(1H)-Isoquinolinecarboxylic acid, 6-(cyclopropylmethoxy)-3,4-dihydro-4-hydroxy-, 1,1-dimethylethyl ester

Participants

Reaction Steps

1.50 g (5.65 mmol) 4,6-Dihydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (example XLII), 840 mg (6.22 mmol) (bromomethyl)cyclopropane and 1.60 g (11.3 mmol) K2CO3 in 10 mL DMF are stirred at 80° C. over night. The reaction mixture is diluted with water and extracted with DCM. The organic layer is concentrated by evaporation and the residue is purified by HPLC.

Provenance & Evidence