Potassium Carbonate → HCID 118939063, compound

Participants

Reaction Steps

15 mg (39 μmol) 2-[4-((S)-1-Acetylamino-ethyl)-benzyl]-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester (example XXXVIII), 5.8 mg (43 μmol) (bromomethyl)cyclopropane and 10 mg (78 μmol) K2CO3 in 2 mL DMF are stirred at 80° C. over night. The reaction mixture is diluted with water and extracted with DCM. The organic layer is concentrated by evaporation and the residue is purified by HPLC.

Provenance & Evidence