反应详情

温度

180 °C

A stirred mixture of 2-amino-5-bromo-3-fluorobenzaldehyde (2.17 g, 10 mmol) and urea (9 g, 150 mmol) was heated at 180° C. for 2 h. LCMS showed the reaction was completed. The reaction mixture was cooled to RT, and the resulting precipitate was filtered and washed with water (500 mL*3). The moisture trapped was completely removed by the co-evaporation with toluene three times. The title compound (2 g, 83%) was obtained as a yellow solid. MS (ES+) C8H4BrFN2O requires: 242, 244. found: 243, 245 [M+H]+.

1. temperatureThe reaction mixture was cooled to RT
2. filtrationthe resulting precipitate was filtered
3. washwashed with water (500 mL*3)
4. customThe moisture trapped was completely removed by the co-evaporation with toluene three times