Pyruvic Acid → 2-(2-Carbamothioylhydrazono)propanoic acid
Reaction equation
[NH2:1][NH:2][C:3]([NH2:5])=[S:4].[C:6]([OH:11])(=[O:10])[C:7]([CH3:9])=O>O>[C:3]([NH:2][N:1]=[C:7]([CH3:9])[C:6]([OH:11])=[O:10])(=[S:4])[NH2:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
To a mixture of thiosemicarbazide (2) (4.55 g, 50.0 mmol) in water (90 mL) was added pyruvic acid (1) (4.40 g, 50.0 mmol). The mixture was heated at 70° C. for 20 min (while a white solid precipitated). After cooling to room temperature, the white solid was collected by filtration, washed with water and dried in air to give 2-(2-carbamothioylhydrazono)propanoic acid (3).
Workup
- customprecipitated)
- temperatureAfter cooling to room temperature
- filtrationthe white solid was collected by filtration
- washwashed with water
- customdried in air
Sources & evidence
- ORD record
- ord-1c12b9d2908a475bad12c09d327f99cb
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09340523B2
Reaction notes
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