HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one | HCID 66616407 | — |
Reaction Steps
The hydrochloride of the title compound (compound B1*HCl) is suspended in water, and the aqueous layer is basified with 5 M aqueous sodium hydroxide solution to a pH above 10. The aqueous phase is extracted three times with DCM, dried over MgSO4 and concentrated in vacuo resulting in the title compound. (compound B1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340522B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-bd1cec19dbd9424a87c23aff15f5b52c |
| Source note | uspto-grants-2016_05 |