Hydrochloric Acid → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

HRID 524292Notes

Reaction equation

HRID 524292 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[C:14]([CH3:26])([CH3:25])[C:15](=[O:24])[N:16]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:17]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].[OH-].[Na+]>O>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[C:14]([CH3:26])([CH3:25])[C:15](=[O:24])[N:16]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:17]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2×

Product 1

HCID 666164075-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The hydrochloride of the title compound (compound B1*HCl) is suspended in water, and the aqueous layer is basified with 5 M aqueous sodium hydroxide solution to a pH above 10. The aqueous phase is extracted three times with DCM, dried over MgSO4 and concentrated in vacuo resulting in the title compound. (compound B1)

Workup

  1. extractionThe aqueous phase is extracted three times with DCM
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bd1cec19dbd9424a87c23aff15f5b52c
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

Loading…