Hydrazine hydrate (1:1) → 5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

HRID 524306Notes

Reaction equation

HRID 524306 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([C:16](=O)[C:17]([CH3:23])([CH3:22])[C:18](OC)=[O:19])[CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:3][CH2:2]1.O.[NH2:26][NH2:27]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([C:16]3[C:17]([CH3:23])([CH3:22])[C:18](=[O:19])[NH:26][N:27]=3)[CH:9]=[CH:10][C:11]=2[O:12][CH:13]([F:15])[F:14])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66616523Methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate2×

Product 1

HCID 666164295-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

Procedure

Prepared analogously as described for the example C1 using methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate (compound D3) and hydrazine hydrate as starting compounds.

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-712f531740ca4143a2d47a414290b6c7
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

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