Oxalyl chloride → 5-(Benzyloxy)-2-methylbenzoyl chloride

HRID 524320Notes

Reaction equation

HRID 524320 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14](O)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:22])=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14]([Cl:22])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 597600475-(Benzyloxy)-2-methylbenzoic acid2×

Product 1

HCID 866574365-(Benzyloxy)-2-methylbenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 3.3 g 5-(benzyloxy)-2-methylbenzoic acid (compound F1) in 80 ml DCM are added 1.4 ml of oxaloylchloride, and the reaction is stirred at RT over night under a blanket of nitrogen. The solvent is removed under reduced pressure yielding the title compound, which was used without further purification.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-2cfccea2aea04d5cab4c9ef385a394f4
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

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