HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Difluoromethyl-phenylboronic acid → 5-(3-Difluoromethyl-phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-thiophen-2-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Difluoromethyl-phenylboronic acid | HCID 44717244 | — |
| Reactant | 5-Bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-thiophen-2-ylmethyl)-amide | HCID 89982807 | — |
| Product | 5-(3-Difluoromethyl-phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-thiophen-2-ylmethyl)-amide | HCID 89982809 | — |
Reaction Steps
Example 40 is prepared following the procedure for Example 24.1, substituting preparation 24 with preparation 39a and replacing 3-(trifluoromethyl)phenylboronic acid with 3-(difluoromethyl)phenylboronic acid. ESI mass spectrum: [M+H]+=495; Retention time HPLC: 0.82 min (Z011_S03).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340507B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-d807105bbafc409190552bf0eb805327 |
| Source note | uspto-grants-2016_05 |