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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524355Generated: October 25, 2026

3-Difluoromethyl-phenylboronic acid → (R)-5-(3-Difluoromethyl-phenyl)-1-(2-methoxy-1-methyl-ethyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide

https://huagongshe.com/reaction/524355

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Difluoromethyl-phenylboronic acidHCID 44717244—
Reactant(R)-5-Bromo-1-(2-methoxy-1-methyl-ethyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamideHCID 89978794—
Product(R)-5-(3-Difluoromethyl-phenyl)-1-(2-methoxy-1-methyl-ethyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamideHCID 89978697—

Reaction Steps

Example 44 is prepared following the procedure for Example 24.1, substituting preparation 24 with preparation 43c and replacing 3-(trifluoromethyl)phenylboronic acid with 3-(difluoromethyl)phenylboronic acid. ESI mass spectrum: [M+H]+=519; Retention time HPLC: 0.97 min (Z018_S04).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340507B2
Source datasetuspto-grants-2016_05
ORD IDord-fca7e6965e9f4e1ba99e5104a0a37065
Source noteuspto-grants-2016_05