反应详情

温度

80 °C

8.56 g (0.05 mol) of 2-furfurylthioacetamide, 5.61 g (0.055 mol) of acetic anhydride, and 6.11 g (0.05 mol) of N,N-dimethyl-aminopyridine were dissolved in 50 ml of pyridine. The mixture was stirred at 80° C. for 16 hours. The solvent was distilled away from the reaction mixture, and the residue thus obtained was added to ethyl acetate and washed successively with water, 1N hydrochloric acid, water three times, and brine. A resultant organic extract layer was dried, and the solvent was distilled away therefrom, so that N-acetyl-2-furfurylthioacetamide was obtained in a yield of 7.11 g (60%).

1. distillationThe solvent was distilled away from the reaction mixture
2. customthe residue thus obtained
3. washwashed successively with water, 1N hydrochloric acid, water three times, and brine
4. customA resultant organic extract layer was dried
5. distillationthe solvent was distilled away