Benzoyl chloride → HCID 19963672, compound

HRID 52437Notes

Reaction equation

HRID 52437 reaction equation
[CH2:1]([CH2:7][C:8]([NH2:10])=[S:9])[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1.[C:11](Cl)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(OCC)(=O)C>N1C=CC=CC=1>[C:11]([NH:10][C:8](=[S:9])[CH2:7][CH2:1][C:2]1[O:6][CH:5]=[CH:4][CH:3]=1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8857Ethyl AcetateHCID 199636792-Furfurylthioacetamide

Product 1

HCID 19963672HCID 19963672, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

12.11 g (0.07 mol) of 2-furfurylthioacetamide was dissolved in 30 ml of pyridine. To the above solution, 9.94 g (0.07 mol) of benzoylchloride was added, and the mixture was stirred at 60° C. for 15 hours. The solvent was distilled away from the reaction mixture, and a residue thus obtained was added to ethyl acetate and washed successively with water twice, 1N hydrochloric acid, water three times, and brine. A resultant organic extract layer was dried, and the solvent was distilled away therefrom.

Workup

  1. distillationThe solvent was distilled away from the reaction mixture
  2. customa residue thus obtained
  3. washwashed successively with water twice
  4. customA resultant organic extract layer was dried
  5. distillationthe solvent was distilled away

Sources & evidence

ORD record
ord-8daf3d01e7a4411b93e67d7293813538
Source dataset
uspto-grants-1997_04
Patent number
US05616711

Reaction notes

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