Trifluoroacetic acid → HCID 86669543, compound

HRID 524407Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:31])[C:5]([C:8]1[N:9]=[C:10]([N:14](C(OC(C)(C)C)=O)CC2C=CC(OC)=CC=2)[S:11][C:12]=1[F:13])([CH3:7])[CH3:6])[CH3:2].C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:31])[C:5]([C:8]1[N:9]=[C:10]([NH2:14])[S:11][C:12]=1[F:13])([CH3:7])[CH3:6])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67378244HCID 67378244, compound

Product 1

HCID 86669543HCID 86669543, compoundYield 97.8%

Procedure

The reaction was done by the same way as mentioned in the preparation 45, step-V using 2-{2-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-5-fluoro-thiazol-4-yl}-2-methyl-propionic acid ethyl ester (0.5 g, 1.1 mmol) and TFA (5 mL) to afford 2-(2-Amino-5-fluoro-thiazol-4-yl)-2-methyl-propionic acid ethyl ester (0.25 g).

Sources & evidence

ORD record: ord-ab6a8a35577a4539b1765beb5fe15696
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340506B2

Reaction notes

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