反应详情

2-(4-Cyclopropylsulfonylphenyl)-2-tetrahydropyran-4-yloxy-acetic acid (preparation 4; (1 equi.) and HATU (1.5 equi) was dissolved in DCM. To this solution was added D1PEA (2 equi.) and stirred for 15 minutes followed by addition of 2-aminothiazole (1 equi.) and continued to stir over night at room temperature. Reaction mixture was diluted with dichloromethane, washed with water, brine, dried over anhydrous sodium sulfate, solvent was removed under reduced pressure to get the crude compound which was purified by flash chromatography to get the title product.

1. additionTo this solution was added D1PEA (2 equi.)
2. stirringto stir over night at room temperature
3. customReaction mixture
4. washwashed with water, brine
5. dry with materialdried over anhydrous sodium sulfate, solvent
6. customwas removed under reduced pressure
7. customto get the crude compound which
8. customwas purified by flash chromatography