HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-[(4,4-Dimethyl-2-heptylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-[(4,4-Dimethyl-2-iso-propoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid | HCID 19963705 | — |
| Reactant | Ethyl 4-[(4,4-dimethyl-2-heptylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoate | HCID 19963725 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[(4,4-Dimethyl-2-heptylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid | HCID 19963708 | — |
Reaction Steps
0.0647 g (0.140 mmol) of ethyl 4-[(4,4-dimethyl-2-heptylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoate (Compound 10) in 2 ml of THF, 1 ml of EtOH was reacted with 2 ml of 1N LiOH substantially in accordance with the procedure used for the preparation of 4-[(4,4-dimethyl-2-iso-propoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid (Compound 11). Purification by recrystallization in acetonitrile yielded the title compound as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616712 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-bdfda93f015444d8a9e6d878058ffe32 |
| Source note | uspto-grants-1997_04 |