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HRID52443

反应详情

EQUATION

反应方程式

HRID 52443 的结构方程式

REACTANTS

反应物

3
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CC(C)OC1=Nc2ccc(C#Cc3ccc(C(=O)O)cc3)cc2C(C)(C)C1
HCID19963705

未命名化合物

2 次

结构：CCCCCCCSC1=Nc2ccc(C#Cc3ccc(C(=O)OCC)cc3)cc2C(C)(C)C1
HCID19963725

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CCCCCCCSC1=Nc2ccc(C#Cc3ccc(C(=O)O)cc3)cc2C(C)(C)C1
HCID19963708

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

0.0647 g (0.140 mmol) of ethyl 4-[(4,4-dimethyl-2-heptylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoate (Compound 10) in 2 ml of THF, 1 ml of EtOH was reacted with 2 ml of 1N LiOH substantially in accordance with the procedure used for the preparation of 4-[(4,4-dimethyl-2-iso-propoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid (Compound 11). Purification by recrystallization in acetonitrile yielded the title compound as a yellow powder.

WORKUP

后处理

  1. customPurification
  2. customby recrystallization in acetonitrile