Trifluoroacetic acid → 6-[[2-(4-Cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino) acetyl]amino]pyridine-3-carboxylic acid

Participants

Reaction Steps

To a solution of tert-butyl 6-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino)acetyl]amino]pyridine-3-carboxylate (Example A8; 31 mg, 0.057 mmole) in DCM (1 mL) was added TFA at 0° C. Reaction mixture was stirred at rt for 1 hr. TFA was removed invaccuo, residue was neutralised using sat.NaHCO3 solution, extracted with ethyl acetate (3×10 mL) washed with brine, dried over anhydrous sodium sulfate and concentrated. Product was purified using preparative TLC, provided title compound (0.005 g).

Provenance & Evidence