反应详情

To a solution of tert-butyl 6-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino)acetyl]amino]pyridine-3-carboxylate (Example A8; 31 mg, 0.057 mmole) in DCM (1 mL) was added TFA at 0° C. Reaction mixture was stirred at rt for 1 hr. TFA was removed invaccuo, residue was neutralised using sat.NaHCO3 solution, extracted with ethyl acetate (3×10 mL) washed with brine, dried over anhydrous sodium sulfate and concentrated. Product was purified using preparative TLC, provided title compound (0.005 g).

1. customReaction mixture
2. customTFA was removed invaccuo, residue
3. extractionNaHCO3 solution, extracted with ethyl acetate (3×10 mL)
4. washwashed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated
7. customProduct was purified