HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane → (S)-benzyl 4-benzyl-2,2-dimethylmorpholine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane | HCID 6331 | — |
| Reactant | (S)-benzyl 4-benzyl-2,2-dimethyl-5-oxomorpholine-3-carboxylate | HCID 118118261 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S)-benzyl 4-benzyl-2,2-dimethylmorpholine-3-carboxylate | HCID 118118262 | 85% |
Reaction Steps
(S)-benzyl 4-benzyl-2,2-dimethyl-5-oxomorpholine-3-carboxylate (163 g, 461 mmol) was reacted with a solution of borane in THF (1 mol/L, 692 mL) according to the procedure as described in Example 34, Step B to give the title compound as colorless oil (133 g, 85%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-f94aebf655b841afa8af0b62e3404760 |
| Source note | uspto-grants-2016_05 |