HRID524654

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3340152

Morpholine-3-carboxylic Acid

C5H9NO3

结构：CCOC(=O)C1=C(CBr)NC(c2nc(CC(=O)NC(C)C)cs2)=NC1c1ccc(F)cc1Br

HCID118107584

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1=C(CN2CCOCC2C(=O)O)NC(c2nc(CC(=O)NC(C)C)cs2)=NC1c1ccc(F)cc1Br

HCID90043296

未命名化合物

收率 49%

PROCEDURE

实验过程

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-(isopropylamino)-2-oxo ethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.2 g, 2 mmol) was reacted with morpholine-3-carboxylic acid (0.39 g, 3 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.64 g, 49%). The compound was characterized by the following spectroscopic data:

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6b7a4698184460fabee2b488644e3e9
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09340538B2
来源说明: uspto-grants-2016_05

反应 SMILES

[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20]Br)[NH:12][C:11]([C:22]2[S:23][CH:24]=[C:25]([CH2:27][C:28]([NH:30][CH:31]([CH3:33])[CH3:32])=[O:29])[N:26]=2)=[N:10]1.[NH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH:35]1[C:40]([OH:42])=[O:41]>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[N:10]=[C:11]([C:22]2[S:23][CH:24]=[C:25]([CH2:27][C:28]([NH:30][CH:31]([CH3:33])[CH3:32])=[O:29])[N:26]=2)[NH:12][C:13]([CH2:20][N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH:35]2[C:40]([OH:42])=[O:41])=[C:14]1[C:15]([O:17][CH2:18][CH3:19])=[O:16]