3-Morpholinecarboxylic acid → 4-((6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(4-(2-(iso propylamino)-2-oxoethyl)thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid

Participants

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-(isopropylamino)-2-oxo ethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.2 g, 2 mmol) was reacted with morpholine-3-carboxylic acid (0.39 g, 3 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.64 g, 49%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence