Isopropanol → HCID 90043354, compound

HRID 524684Notes

Reaction equation

Cl.[NH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[C:8]([OH:10])=[O:9].O=S(Cl)[Cl:13].[CH:15](O)([CH3:17])[CH3:16]>>[ClH:13].[NH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[C:8]([O:10][CH:15]([CH3:17])[CH3:16])=[O:9]

Participants

Reactant 3

HCID 3776Isopropanol

HCID 24386Thionyl Chloride

HCID 45790954Morpholine-3-carboxylic acid hydrochloride

Product 1

HCID 90043354HCID 90043354, compoundYield 95%

Conditions

Temperature: 80 °C

Procedure

To a suspension of morpholine-3-carboxylic acid hydrochloride (2 g, 12 mmol) in isopropanol (30 mL) was added SOCl2 (1.9 g, 15.6 mmol) at 5° C., then the mixture was stirred at 80° C. for 6 hours. The mixture was concentrated in vacuo to give the title compound as pale brown oil (2.39 g, 95%). The compound was characterized by the following spectroscopic data:

Workup

concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record: ord-64431c196c59485fb2a64218a57a7622
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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