Isopropylamine → N-Isopropylmorpholine-3-carboxamide

HRID 524689Notes

Reaction equation

HRID 524689 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[C:8]([O:10]C)=O.[CH3:12][CH:13]([NH2:15])[CH3:14]>>[CH:13]([NH:15][C:8]([CH:3]1[CH2:4][O:5][CH2:6][CH2:7][NH:2]1)=[O:10])([CH3:14])[CH3:12]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 42614243Methyl morpholine-3-carboxylate hydrochloride

Product 1

HCID 65438161N-Isopropylmorpholine-3-carboxamideYield 96.8%

Conditions

Temperature
60 °C

Procedure

A mixture of methyl morpholine-3-carboxylate hydrochloride (0.22 g, 1.2 mmol) and propan-2-amine (2.78 g, 47 mmol) was stirred at 60° C. for 12 hours under N2. The mixture was concentrated in vacuo to give the title compound as brownish sticky oil (0.2 g, 95%). The compound was characterized by the following spectroscopic data:

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cf4d848587a04352be69af03b8bd2d04
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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