Ammonium Chloride → 1-methyl-1H-1,2,4-triazole-3-carboximidamide hydrochloride

HRID 524692Notes

Reaction equation

[CH3:1][N:2]1[CH:6]=[N:5][C:4]([C:7]#[N:8])=[N:3]1.C[O-].[Na+].[Cl-:12].[NH4+:13]>>[ClH:12].[CH3:1][N:2]1[CH:6]=[N:5][C:4]([C:7](=[NH:13])[NH2:8])=[N:3]1

Participants

Reactant 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 607103171-methyl-1H-1,2,4-triazole-3-carbonitrile

Product 1

HCID 900441211-methyl-1H-1,2,4-triazole-3-carboximidamide hydrochlorideYield 78.8%

Procedure

1-methyl-1H-1,2,4-triazole-3-carbonitrile (20 g, 185 mmol) was reacted with sodium methoxide (14 g, 295 mmol) and ammonium chloride (14.8 g, 277.5 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (23.44 g, 78.8%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-ca98bc871af843d284830ebbfdef4d73
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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