Ethyl bromoacetate → ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate

HRID 524708Notes

Reaction equation

Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH:8]1[CH:12]=[N:11][C:10]([C:13]#[N:14])=[N:9]1>>[C:13]([C:10]1[N:11]=[CH:12][N:8]([CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[N:9]=1)#[N:14]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 178510603HCID 178510603, compound

Product 1

HCID 60710264ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetateYield 84%

Procedure

Ethyl 2-bromoacetate (8.88 g, 53.15 mmol) was reacted with 1H-1,2,4-triazole-3-carbonitrile (5 g, 53.15 mmol) according to the procedure as described in Example 48, Step A to give the title compound as a white solid (8 g, 84%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-4a507fc4a3e5454492a924019470fe63
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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