Ethyl bromoacetate → ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate

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Reaction Steps

Ethyl 2-bromoacetate (8.88 g, 53.15 mmol) was reacted with 1H-1,2,4-triazole-3-carbonitrile (5 g, 53.15 mmol) according to the procedure as described in Example 48, Step A to give the title compound as a white solid (8 g, 84%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence