Ethyl Acetoacetate → Ethyl 4-(2,4-dichlorophenyl)-2-(3-fluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate

Participants

Reaction Steps

3-fluoropicolinimidamide hydrochloride (5.53 g, 31.5 mmol) was reacted with 2,4-dichlorobenzaldehyde (5.51 g, 31.5 mmol) and ethyl 3-oxobutanoate (4.1 g, 31.5 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (6.94 g, 54%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence