Morpholine-2-carboxylic acid hydrochloride → HCID 73297048, compound

HRID 524736Notes

Reaction equation

HRID 524736 reaction equation
Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[N:6][CH:5]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[C:4]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].Cl.[NH:29]1[CH2:34][CH2:33][O:32][CH:31]([C:35]([OH:37])=[O:36])[CH2:30]1>>[Cl:22][C:16]1[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=1[CH:5]1[N:6]=[C:7]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[NH:8][C:3]([CH2:2][N:29]2[CH2:34][CH2:33][O:32][CH:31]([C:35]([OH:37])=[O:36])[CH2:30]2)=[C:4]1[C:23]([O:25][CH2:26][CH3:27])=[O:24]

Participants

3

Reactant 2

HCID 42614320Morpholine-2-carboxylic acid hydrochlorideHCID 118107570HCID 118107570, compound

Product 1

HCID 73297048HCID 73297048, compoundYield 56.5%

Procedure

Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-1,4-dihydro-[2,2′-bipyrimidine]-5-carboxylate (0.72 g, 1.53 mmol) (The compound was synthesized according to the procedure as described in WO2010069147) was reacted with morpholine-2-carboxylic acid hydrochloride (0.26 g, 1.53 mmol) according to the procedure as described in Example 28 to give the title compound as a yellow solid (0.45 g, 56%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-42bf088abccb46b19246cbeea4dac418
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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