3-Morpholinecarboxylic acid → HCID 73296880, compound

HRID 524741Notes

Reaction equation

HRID 524741 reaction equation
Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[N:10]=[CH:11][S:12][C:13]=2[Cl:14])=[N:6][CH:5]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[C:4]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH:29]1[C:34]([OH:36])=[O:35]>>[Cl:14][C:13]1[S:12][CH:11]=[N:10][C:9]=1[C:7]1[NH:8][C:3]([CH2:2][N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH:29]2[C:34]([OH:36])=[O:35])=[C:4]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:5]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[N:6]=1

Participants

3

Reactant 2

HCID 33401523-Morpholinecarboxylic acidHCID 118107528HCID 118107528, compound

Product 1

HCID 73296880HCID 73296880, compoundYield 34%

Procedure

Ethyl 6-(bromomethyl)-2-(5-chlorothiazol-4-yl)-4-(2,4-dichlorophenyl)-1,4-dihydropyrimidine-5-carboxylate (0.78 g, 1.53 mmol) was reacted with morpholine-3-carboxylic acid (0.2 g, 1.53 mmol) according to the procedure as described in Example 28 to give the title compound as a yellow solid (0.29 g, 34%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-e5134c1aa921411bbc7038d363674c1f
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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