Ammonium Chloride → 1,2,4-Thiadiazole-5-carboximidamide hydrochloride

HRID 524748Notes

Reaction equation

[S:1]1[C:5]([C:6]#[N:7])=[N:4][CH:3]=[N:2]1.C[O-].[Na+].[Cl-:11].[NH4+:12]>>[ClH:11].[S:1]1[C:5]([C:6](=[NH:12])[NH2:7])=[N:4][CH:3]=[N:2]1

Participants

Reactant 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 824189881,2,4-Thiadiazole-5-carbonitrile

Product 1

HCID 900431421,2,4-Thiadiazole-5-carboximidamide hydrochloride

Procedure

1,2,4-thiadiazole-5-carbonitrile (1.11 g, 10 mmol) was reacted with sodium methoxide (0.81 g, 15 mmol) and ammonium chloride (0.96 g, 18 mmol) according to the procedure as described in Example 61, Step B to give the title compound as an offwhite solid (1.32 g, 80%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-74062f668da948ef92dc90c1de536c62
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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