Ammonium Chloride → 1,2,4-Thiadiazole-5-carboximidamide hydrochloride

Participants

Reaction Steps

1,2,4-thiadiazole-5-carbonitrile (1.11 g, 10 mmol) was reacted with sodium methoxide (0.81 g, 15 mmol) and ammonium chloride (0.96 g, 18 mmol) according to the procedure as described in Example 61, Step B to give the title compound as an offwhite solid (1.32 g, 80%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence