HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(5H-tetrazol-5-yl)morpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-(5H-tetrazol-5-yl)morpholine-4-carboxylate | HCID 90043836 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(5H-tetrazol-5-yl)morpholine hydrochloride | HCID 90043436 | 70% |
Reaction Steps
Tert-butyl 3-(5H-tetrazol-5-yl)morpholine-4-carboxylate (2 g, 7.8 mmol) was reacted with a solution of HCl in EtOAc (6 mol/L, 30 mL) according to the procedure as described in Example 18, Step B to give the title compound as a grey solid (1.05 g, 70%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-6e912af3ea4548d89de5bb12d015fa50 |
| Source note | uspto-grants-2016_05 |