Hydrochloric Acid → 3-(5H-tetrazol-5-yl)morpholine hydrochloride

HRID 524759Notes

Reaction equation

HRID 524759 reaction equation
[N:1]1[CH:5]([CH:6]2[CH2:11][O:10][CH2:9][CH2:8][N:7]2C(OC(C)(C)C)=O)[N:4]=[N:3][N:2]=1.[ClH:19]>CCOC(C)=O>[ClH:19].[N:4]1[CH:5]([CH:6]2[CH2:11][O:10][CH2:9][CH2:8][NH:7]2)[N:1]=[N:2][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90043836Tert-butyl 3-(5H-tetrazol-5-yl)morpholine-4-carboxylate

Product 1

HCID 900434363-(5H-tetrazol-5-yl)morpholine hydrochlorideYield 70%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl 3-(5H-tetrazol-5-yl)morpholine-4-carboxylate (2 g, 7.8 mmol) was reacted with a solution of HCl in EtOAc (6 mol/L, 30 mL) according to the procedure as described in Example 18, Step B to give the title compound as a grey solid (1.05 g, 70%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-6e912af3ea4548d89de5bb12d015fa50
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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