Ethyl Acetoacetate → HCID 118107605, compound

HRID 524772Notes

Reaction equation

HRID 524772 reaction equation
C(O)(=O)C.[F:5][C:6]1[S:10][C:9]([C:11](=[NH:13])[NH2:12])=[N:8][CH:7]=1.[Cl:14][C:15]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:16]=1[CH:17]=O.O=[C:25]([CH3:32])[CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28]>>[Cl:14][C:15]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:16]=1[CH:17]1[C:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:25]([CH3:32])[NH:12][C:11]([C:9]2[S:10][C:6]([F:5])=[CH:7][N:8]=2)=[N:13]1

Participants

4

Reactant 3

HCID 8868Ethyl AcetoacetateHCID 134042,4-DichlorobenzaldehydeHCID 90043393HCID 90043393, compound

Product 1

HCID 118107605HCID 118107605, compoundYield 81.1%

Procedure

5-fluorothiazole-2-carboximidamide acetate (0.25 g, 1.22 mmol) was reacted with 2,4-dichlorobenzaldehyde (0.21 g, 1.22 mmol) and ethyl 3-oxobutanoate (0.16 g, 1.22 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (0.41 g, 80%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-38eefd3cf0994172a47dc00ba326b374
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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