HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine-3-carboxylic acid hydrochloride → HCID 118107575, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine-3-carboxylic acid hydrochloride | HCID 45790954 | — |
| Reactant | Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(1-methyl-1H-1,2,4-triazol-3-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 90043165 | — |
| Product | HCID 118107575 | HCID 118107575 | 45.3% |
Reaction Steps
Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(1-methyl-1H-1,2,4-triazol-3-yl)-1,4-dihydropyrimidine-5-carboxylate (0.5 g, 1 mmol) was reacted with morpholine-3-carboxylic acid hydrochloride (0.17 g, 1 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.25 g, 45%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-01a6f1e97cb64093834fc2d21312cf20 |
| Source note | uspto-grants-2016_05 |